SINCE Wwii, medical science has progressed with a stage where competitive medications are for sale to treat the same ailment in numerous people. This is not pretty much brands (the trade issue) but generic drugs (the scientific issue). In this report, we shall consider the various factors that decide selecting a specific drug.
Safety: The following sub-criteria should be considered underneath the criterion of safety:
* Acute therapeutic index: In the event the patient’s condition is acute, how effective is really a particular drug regardless of whether it’s got certain side-effects as long as the acuteness of the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but come with the possible side-effect of addiction.
* Long-term safety: drug directory might be safe in short-term treatment, but how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in the case of prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and several chemicals answer develop a different chemical, which has an effect that may harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from each other, have certain effects one or maybe more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is determined by for the metabolism. This will cause an increase in the side-effects of Lexapro.
· Pharmacodynamic: Here, several drugs actually produce the same impact on the same organ, thus improving the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of both drugs are more intense.
Tolerability: A medication might be effective however, not tolerable by all patients. Example: Allergies to specific drugs in a few people. Short-term and long-term tolerability must be looked at. Efficacy: A medication is just not equally good at all patients. For instance, some patients with depression or panic disorders experience respite from escitalopram, but there are lots of who don’t, who therefore must be prescribed a different anti-depressant. The pace of oncoming of therapeutic action is a crucial key to be looked at too.
Cost: Cost does not necessarily mean the price tag on acquiring a specific medicine alone. It will also cover the price tag on management of a complication that may arise from using a different drug. Example: In the person who insists on taking alcohol nevertheless needs to be treated for depression is often administered an SSRI drug as these drugs don’t potentiate the end results of alcohol, whereas another band of anti-depressants (including tricyclics) can cause a brand new condition in such patients, which could need a different and expensive treatment. Therefore, it’s safer to prescribe the more costly escitalopram rather than a cheaper tricyclic in such patients.
Simplicity of treatment: The best mode of administration is preferred. If there is a choice between a shot and oral administration, the latter is preferred if your efficacy of both modes is analogous. Or, local application is chosen over the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key factor to determine simple treatment.
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