SINCE World war 2, medical science has progressed with a stage where competitive medications are around for treat the same ailment in several people. This isn’t almost brands (the industry trade issue) but generic drugs (the industry scientific issue). On this report, we shall glance at the various factors that decide your selection of a selected drug.
Safety: These sub-criteria has to be considered beneath the criterion of safety:
* Acute therapeutic index: If the patient’s condition is acute, how effective is really a particular drug even though it has certain side-effects provided that the acuteness of the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but have the possible side-effect of addiction.
* Long-term safety: drug may be safe in short-term treatment, so how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and many chemicals answer create a different chemical, which has an effect that will harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from one another, have certain effects on one or higher body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends upon because of its metabolism. This makes a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, several drugs actually create the same effect on the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of both the drugs are more intense.
Tolerability: A medicine may be effective although not tolerable by all patients. Example: Allergies to a particular drugs in most people. Short-term and long-term tolerability need to be looked at. Efficacy: A medicine isn’t equally efficient at all patients. By way of example, some patients with depression or anxiety disorders experience respite from escitalopram, but there are lots of who don’t, who therefore need to be prescribed some other anti-depressant. The rate of start of therapeutic action is a key to be looked at too.
Cost: Cost does not mean the cost of purchase of a specific medicine alone. It ought to also cover the cost of management of a complication that will arise by using some other drug. Example: In a individual who insists on taking alcohol nevertheless must be treated for depression is often administered an SSRI drug since these drugs don’t potentiate the consequences of alcohol, whereas another gang of anti-depressants (including tricyclics) might cause a fresh symptom in such patients, which may have to have a different and expensive treatment. Therefore, it’s easier to prescribe the more costly escitalopram rather than cheaper tricyclic such patients.
Simplicity of treatment: The simplest mode of administration is preferred. If there is an alternative between a shot and oral administration, aforementioned is preferred in the event the efficacy of both the modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are an important factor to decide simple treatment.
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