SINCE The second world war, medical science has progressed to some stage where competitive medications are around for treat the same ailment in different people. This isn’t pretty much brands (the industry trade issue) but generic drugs (the industry scientific issue). In this report, we shall look at the various factors that decide your selection of a particular drug.
Safety: The next sub-criteria must be considered underneath the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective is a particular drug even though it’s certain side-effects as long as the acuteness in the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but come with the possibility side-effect of addiction.
* Long-term safety: medicine might be safe in short-term treatment, but wait, how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in case there is prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and many chemicals react to create a different chemical, which has an effect that will harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to make a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from each other, have certain effects on a single or more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by due to the metabolism. This will cause a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually make the same influence on the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of the prescription medication is more serious.
Tolerability: A medication might be effective although not tolerable by all patients. Example: Allergies to specific drugs in some people. Short-term and long-term tolerability need to be taken into account. Efficacy: A medication isn’t equally efficient at all patients. For instance, some patients with depression or panic attacks experience reduced escitalopram, but there are several that don’t, who therefore need to be prescribed a different anti-depressant. The speed of oncoming of therapeutic action is an important step to be regarded too.
Cost: Cost does not necessarily mean the expense of acquiring a particular medicine alone. It ought to also cover the expense of management of a complication that will arise while using a different drug. Example: In a person who insists on taking alcohol but has to be treated for depression is normally administered an SSRI drug as these drugs don’t potentiate the effects of alcohol, whereas another number of anti-depressants (including tricyclics) might cause a fresh condition in such patients, which will have to have a different and expensive treatment. Therefore, it’s safer to prescribe the more costly escitalopram rather than cheaper tricyclic such patients.
Simple treatment: The best mode of administration is preferred. When there is an option between an injection and oral administration, the latter is preferred when the efficacy of the modes is comparable. Or, local application is chosen over the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key point to determine simple treatment.
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