SINCE Wwii, medical science has progressed with a stage where competitive medications are around to treat exactly the same ailment in different people. This is simply not just about brands (that is a trade issue) but generic drugs (that is a scientific issue). Within this report, we shall glance at the various factors that decide your selection of a particular drug.
Safety: The following sub-criteria should be considered beneath the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective can be a particular drug regardless of whether they have certain side-effects as long as the acuteness in the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but feature the possibility side-effect of addiction.
* Long-term safety: medication directory may be safe in short-term treatment, but exactly how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in the case of prolonged use.
* Drug-drug interaction risk: Prescription medication is chemicals, and several chemicals reply to produce a different chemical, which has an effect that could harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to make a new condition that warrants separate treatment.
Drug-drug interaction risk is of 2 types:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, independent of one another, have certain effects on a single or higher body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends on for its metabolism. This makes an increase in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually produce the same impact on exactly the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of the two medicines are more serious.
Tolerability: A medication may be effective and not tolerable by all patients. Example: Allergies to certain drugs in most people. Short-term and long-term tolerability need to be looked at. Efficacy: A medication isn’t equally effective in all patients. For instance, some patients with depression or panic disorders experience respite from escitalopram, but there are many who don’t, who therefore need to be prescribed another anti-depressant. The speed of oncoming of therapeutic action is a crucial key to be looked at too.
Cost: Cost does not always mean the price tag on acquisition of a certain medicine alone. It must also cover the price tag on management of a complication that could arise from utilizing another drug. Example: Within a individual who insists on taking alcohol but needs to be treated for depression is generally administered an SSRI drug because these drugs don’t potentiate the results of alcohol, whereas another band of anti-depressants (including tricyclics) might cause a whole new symptom in such patients, which may require a various and expensive treatment. Therefore, it’s easier to prescribe the more expensive escitalopram rather than cheaper tricyclic in this patients.
Simplicity of treatment: The simplest mode of administration is preferred. When there is a selection between an injection and oral administration, aforementioned is preferred if the efficacy of the two modes is comparable. Or, local application is chosen over the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key point to decide simplicity of treatment.
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