SINCE Wwii, medical science has progressed to a stage where competitive medications are around for treat the identical ailment in several people. This is simply not nearly brands (which is a trade issue) but generic drugs (which is a scientific issue). In this report, we shall go through the various factors that decide your selection of a selected drug.
Safety: The subsequent sub-criteria must be considered within the criterion of safety:
* Acute therapeutic index: In the event the patient’s condition is acute, how effective is a particular drug regardless of whether it’s got certain side-effects as long as the acuteness with the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but feature the possible side-effect of addiction.
* Long-term safety: drug could possibly be safe in short-term treatment, but wait, how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in case there is prolonged use.
* Drug-drug interaction risk: Drugs are chemicals, and many chemicals react to produce a different chemical, that have an effect that will harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from each other, have certain effects on a single or more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends on because of its metabolism. This makes a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually create the same impact on the identical organ, thus improving the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of the prescription medication is more intense.
Tolerability: A drug could possibly be effective although not tolerable by all patients. Example: Allergies to particular drugs in most people. Short-term and long-term tolerability should be taken into consideration. Efficacy: A drug is just not equally efficient at all patients. As an example, some patients with depression or anxiety attacks experience reduced escitalopram, but there are several that do not, who therefore should be prescribed some other anti-depressant. The rate of start of therapeutic action is an important the answer to be regarded as too.
Cost: Cost does not always mean the cost of acquisition of a particular medicine alone. It must also cover the cost of treating a complication that will arise by using some other drug. Example: In the individual that insists on taking alcohol and yet should be treated for depression is often administered an SSRI drug because these drugs don’t potentiate the effects of alcohol, whereas another group of anti-depressants (such as tricyclics) might cause a whole new condition in such patients, which may require a various and expensive treatment. Therefore, it’s easier to prescribe the more costly escitalopram rather than a cheaper tricyclic in these patients.
Simple treatment: The best mode of administration is preferred. If you have a choice between an injection and oral administration, rogues is preferred if your efficacy of the modes can be compared. Or, local application is preferred to the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are a key factor to decide simple treatment.
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