SINCE World war 2, medical science has progressed with a stage where competitive medications are around for treat the identical ailment in various people. It’s not just about brands (the industry trade issue) but generic drugs (the industry scientific issue). In this report, we shall look at the various factors that decide your selection of a particular drug.
Safety: The following sub-criteria should be considered within the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective can be a particular drug regardless of whether it’s certain side-effects providing the acuteness with the condition is lowered? Example: narcotic pain-killers work well in healing pain but include the possible side-effect of addiction.
* Long-term safety: drug could be safe in short-term treatment, so how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Prescription medication is chemicals, and several chemicals reply to produce a different chemical, that have an effect that will harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of one another, have certain effects one or even more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by for its metabolism. This leads to more the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually generate the same relation to the identical organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of both prescription medication is more serious.
Tolerability: A drug could be effective however, not tolerable by all patients. Example: Allergies to specific drugs in certain people. Short-term and long-term tolerability should be considered. Efficacy: A drug just isn’t equally effective in all patients. As an example, some patients with depression or panic disorders experience relief from escitalopram, but there are several who don’t, who therefore should be prescribed an alternative anti-depressant. The speed of beginning of therapeutic action is a crucial factor to be looked at too.
Cost: Cost does not always mean the price tag on acquiring a specific medicine alone. It must also cover the price tag on treatments for a complication that will arise by using an alternative drug. Example: Inside a individual that insists on taking alcohol yet needs to be treated for depression is often administered an SSRI drug since these drugs don’t potentiate the results of alcohol, whereas another band of anti-depressants (for example tricyclics) might cause a brand new problem in such patients, which will demand a different and expensive treatment. Therefore, it’s preferable to prescribe the more costly escitalopram instead of a cheaper tricyclic in these patients.
Simple treatment: Most effective mode of administration is preferred. If you find an alternative between an injection and oral administration, the latter is preferred in the event the efficacy of both modes is comparable. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are an important factor to make a decision simplicity of treatment.
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