SINCE World War II, medical science has progressed to a stage where competitive medications are around to treat exactly the same ailment in numerous people. This is simply not nearly brands (which is a trade issue) but generic drugs (which is a scientific issue). With this report, we shall look at the various factors that decide picking a a particular drug.
Safety: These sub-criteria must be considered under the criterion of safety:
* Acute therapeutic index: If the patient’s condition is acute, how effective can be a particular drug even if it has certain side-effects as long as the acuteness from the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but have the potential side-effect of addiction.
* Long-term safety: drug directory could be safe in short-term treatment, but wait, how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in the case of prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and many chemicals react to develop a different chemical, which has an effect which could harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to make a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of the other person, have certain effects on one or higher body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is determined by for its metabolism. This will cause a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually generate the same impact on exactly the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of both drugs are more intense.
Tolerability: A medicine could be effective and not tolerable by all patients. Example: Allergies to particular drugs in certain people. Short-term and long-term tolerability must be considered. Efficacy: A medicine isn’t equally effective in all patients. As an example, some patients with depression or panic disorders experience rest from escitalopram, but there are numerous who don’t, who therefore must be prescribed some other anti-depressant. The rate of start of therapeutic action is a crucial factor to be looked at too.
Cost: Cost does not necessarily mean the cost of acquiring a specific medicine alone. It should also cover the cost of treatments for a complication which could arise from utilizing some other drug. Example: Inside a one who insists on taking alcohol nevertheless must be treated for depression is generally administered an SSRI drug because these drugs don’t potentiate the results of alcohol, whereas another group of anti-depressants (including tricyclics) may cause a new condition in such patients, which may have to have a various and expensive treatment. Therefore, it’s safer to prescribe the more costly escitalopram rather than a cheaper tricyclic in these patients.
Simple treatment: Most effective mode of administration is preferred. When there is an alternative between an injection and oral administration, rogues is preferred if the efficacy of both modes is comparable. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are a key factor to determine simplicity of treatment.
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